TREATMENT-RESISTANT DEPRESSION (TRD)

The future of
depression treatment
over.

When conventional treatments are not enough, depression may require a different clinical approach. At AlmaraClinic, we combine medical assessment, psychiatric care, and ExoTMS® technology within a personalized treatment plan.

MAJOR DEPRESSIVE DISORDER

When depression goes
beyond sadness.

Major Depressive Disorder is a clinical mental health condition that can affect mood, energy, sleep, appetite, motivation, concentration, and the ability to function in everyday life.

It is not a matter of willpower. Depression involves measurable changes in brain circuits responsible for emotional regulation, motivation, decision-making, and the stress response.

In some cases, symptoms persist despite medication and appropriate clinical care. When there is an insufficient response to conventional treatments, the condition may be classified as Treatment-Resistant Depression (TRD).

In these situations, additional evidence-based medical approaches may be considered, always following a specialist assessment and the development of an individualized treatment plan.

Low mood Loss of motivation Persistent fatigue Sleep disturbances Difficulty concentrating Insufficient response to medication
Depressão major e depressão resistente à medicação
depression
Major Depressive Disorder and Treatment-Resistant Depression require expert evaluation and specialized care.

CLINICAL EVIDENCE

More than 30 years of scientific evidence in non-invasive neuromodulation.

Transcranial Magnetic Stimulation (TMS) is an internationally recognized medical technology for the treatment of Major Depressive Disorder, including treatment-resistant depression. It works by stimulating brain regions involved in mood regulation and neural activity.
FDA

FDA-cleared for the treatment of Major Depressive Disorder in patients who have not achieved an adequate response to antidepressant medication.

0%

Clinical response rate reported in TMS protocols for Treatment-Resistant Depression (TRD).*

30–50%

Patients may achieve clinical remission following a complete course of treatment.*

18,5

Minutes per ExoTMS® session, enabling faster treatment protocols than conventional TMS.

The results presented are based on published clinical studies and international research. Individual outcomes may vary depending on the patient’s clinical profile and treatment plan.

01

More than 30 years of research.

Transcranial Magnetic Stimulation has been studied since the 1980s and continues to be one of the fastest-growing fields in neuromodulation research.

02

Thousands of published studies.

The safety and effectiveness of TMS are supported by thousands of peer-reviewed publications, clinical trials, and systematic reviews.

03

International clinical guidelines.

Recommended by leading international scientific organizations for treatment-resistant depression, obsessive-compulsive disorder (OCD), and other clinical indications.

04

No surgery. No anesthesia.

Treatment is performed on an outpatient basis, allowing patients to return to their normal daily activities immediately after each session.

BOOK AN ASSESSMENT

When depression persists,
it’s time to explore new possibilities.

Complete the form and our team will contact you to schedule a clinical assessment, review your medical history, and determine whether neuromodulation may be an appropriate treatment option for you.

Having more questions?

O que é a depressão resistente ao tratamento?

Fala-se em depressão resistente quando os sintomas não melhoram de forma satisfatória após tentativas adequadas de tratamento com medicação.

O TMS é eficaz na depressão resistente?

A estimulação magnética transcraniana é uma alternativa clinicamente validada para a depressão, incluindo casos resistentes à medicação. A adequação ao seu caso é avaliada em consulta médica.

How many treatment sessions will I need?

Treatment typically ranges from 6 to 30 sessions, depending on the medical prescription established after your assessment and your clinical progress.

Como posso começar?

O primeiro passo é marcar o NeuroCheck gratuito ou uma consulta de avaliação através da página de contactos.